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Genomic signatures: tracing the origin of retroelements at the nucleotide level

Identifieur interne : 000310 ( France/Analysis ); précédent : 000309; suivant : 000311

Genomic signatures: tracing the origin of retroelements at the nucleotide level

Auteurs : Christophe Terzian [France] ; Ivan Laprevotte [France] ; Sophie Brouillet [France] ; Alain Hénaut [France]

Source :

RBID : ISTEX:A6C890D00A23FCC792DE92E1E0C57CBC4959C7F4

Descripteurs français

English descriptors

Abstract

Abstract: We investigate the nucleotide sequences of 23 retroelements (4 mammalian retroviruses, 1 human, 3 yeast, 2 plant, and 13 invertebrate retrotransposons) in terms of their oligonucleotide composition in order to address the problem of relationship between retrotransposons and retroviruses, and the coadaptation of these retroelements to their host genomes. We have identified by computer analysis over-represented 3- through 6-mers in each sequence. Our results indicate retrotransposons are heterogeneous in contrast to retroviruses, suggesting different modes of evolution by slippage-like mechanisms. Moreover, we have calculated the Observed/Expected number ratio for each of the 256 tetramers and analysed the data using a multivariate approach. The tetramer composition of retroelement sequences appears to be influenced by host genomic factors like methylase activity.

Url:
DOI: 10.1023/A:1018358301906


Affiliations:


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ISTEX:A6C890D00A23FCC792DE92E1E0C57CBC4959C7F4

Le document en format XML

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